Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery. Dogs were administered 2 mg/lb of Carprofen caplets two hours prior to surgery then once daily, as needed for 2 days (soft tissue surgery) or 3 days (orthopedic surgery). Carprofen was well tolerated when used in conjunction with a variety of anesthetic-related drugs. The type and severity of abnormal health observations in Carprofen- and placebo-treated animals were approximately equal and few in number (see Adverse Reactions ). The most frequent abnormal health observation was vomiting and was observed at approximately the same frequency in Carprofen- and placebo-treated animals. Changes in clinicopathologic indices of hematopoetic, renal, hepatic, and clotting function were not clinically significant. The mean post-treatment serum ALT values were IU and IU less than pre-treatment values for dogs receiving Carprofen and placebo, respectively. The mean post-treatment AST values were IU less for dogs receiving Carprofen and IU greater for dogs receiving placebo.
To understand how an individual may develop anterolisthesis, it is important first to explain the anatomy of the spine, where the condition develops. The main players are the vertebrae, which are stacked along your back to form the spine. They are hollow at the center to provide room for the spinal cord through the spinal canal, which comprises of all the nerves of the body. In terms of structure, the vertebrae are wider at the top and bottom while narrower around the middle to enhance stability when they are stacked on top of each other.