Steroidal sapogenin

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Diosgenin is a steroidal sapogenin present in fenugreek and Dioscorea spp. as glycosides (saponins). Diosgenin has already been reported to inhibit osteoclastogenesis and to stimulate osteogenic activity of osteoblastic cells in vitro, and to exert some antiosteoporotic effects in rats in vivo. The aim of the present study was to investigate the effects of diosgenin administration on the skeletal system of rats with normal estrogen level and with estrogen deficiency induced by bilateral ovariectomy. The experiments were carried out on 3-month-old non-ovariectomized and ovariectomized Wistar rats, divided into control rats and rats receiving diosgenin (50 mg/kg . daily) for 4 weeks. Serum bone turnover markers, bone mass and mineralization, histomorphometric parameters and mechanical properties were studied. Diosgenin improved some investigated parameters in both non-ovariectomized and ovariectomized rats, in which estrogen deficiency induced osteoporotic changes. Diosgenin increased compact bone formation and probably inhibited cancellous bone resorption, which led to improvement of mechanical properties of compact and cancellous bone. In conclusion, this in vivo study demonstrated that diosgenin may be one of sparse compounds increasing bone formation.

Saponins from the Gypsophila paniculata (baby’s breath) plant have been shown to significantly augment the cytotoxicity of immunotoxins and other targeted toxins directed against human cancer cells. The research groups of Professor Hendrik Fuchs ( Charité University, Berlin, Germany) and Dr David Flavell (Southampton General Hospital, United Kingdom) are working together toward the development of Gypsophila saponins for use in combination with immunotoxins or other targeted toxins for patients with leukaemia , lymphoma and other cancers .

2008 – 2018 Adaptogeny .
Toto jsou osobní stránky s tématikou léčivých rostlin a biologického myšlení v medicíně. Není-li uvedeno jinak, jsou veškeré informace zde obsažené osobními názory autora. Tyto informace nenahrazují konzultaci s lékařem ani lékárníkem. Autor neručí za žádnou újmu způsobenou využitím informací zde obsažených, nebo jejich mylnou interpretací. Stránky samozřejmě využívají cookies, proto občané zemí EU tímto potvrzují (dle směrnice Evropské unie 2002/58/EC), že s použitím cookies souhlasí, jinak musí tyto stránky opustit (případně opustit EU). Kopírování obsahu bez souhlasu autora je zakázáno.

Steroidal sapogenin

steroidal sapogenin

2008 – 2018 Adaptogeny .
Toto jsou osobní stránky s tématikou léčivých rostlin a biologického myšlení v medicíně. Není-li uvedeno jinak, jsou veškeré informace zde obsažené osobními názory autora. Tyto informace nenahrazují konzultaci s lékařem ani lékárníkem. Autor neručí za žádnou újmu způsobenou využitím informací zde obsažených, nebo jejich mylnou interpretací. Stránky samozřejmě využívají cookies, proto občané zemí EU tímto potvrzují (dle směrnice Evropské unie 2002/58/EC), že s použitím cookies souhlasí, jinak musí tyto stránky opustit (případně opustit EU). Kopírování obsahu bez souhlasu autora je zakázáno.

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