The new study randomized 40 patients to get either a steroid shot or PRP injection via ultrasound guidance. The patients were then followed only short-term up to three months (which is a weakness of this study). Back pain was less with PRP at six weeks and three months. Only 25% of the patients who had a steroid injection were still experiencing significant relief at three months compared to 90% of the PRP group. Functional scores worsened at three months for the steroid group while these same scores improved gradually for the PRP group. In summary, PRP beat steroid in this small study.
Symptoms from nerves generally take longer to respond to corticosteroid than symptoms relating to muscles or joints. During this time, the normal symptoms might continue or, occasionally, are worse. A major flare of symptoms generally indicates a local reaction to the injected medication or to having the needle. Anti-inflammatory medication, rest (use of a splint) and the application of cold packs is recommended. If the reaction is persistent, then you should seek medical attention, as it might be an infection, although this is unlikely.