Corticosteroids have been shown to reduce fertility when administered to rats. Male rats were administered corticosterone at doses of 0, 10, and 25 mg/kg/day by subcutaneous injection once daily for 6 weeks and mated with untreated females. The high dose was reduced to 20 mg/kg/day after Day 15. Decreased copulatory plugs were observed, which may have been secondary to decreased accessory organ weight. The numbers of implantations and live fetuses were reduced. Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose. In animal reproduction studies, glucocorticoids have been shown to increase the incidence of malformations (cleft palate, skeletal malformations), embryo-fetal lethality (., increase in resorptions), and intra-uterine growth retardation. With hydrocortisone, cleft palate was observed when administered to pregnant mice and hamsters during organogenesis
Last week I was diagnosed with Acute Bronchitis and was given Prednisone 5 x 50mg Prednisone to be taken once per day, as well as a Zpak. On day 3 of the Pred, I started having insomnia. On day 4, started getting terrible anxiety (which I am not historically known for). So, I stopped taking the Pred on day 4. It is now day 10 since starting the Pred, and day 6 since stopping, and I continue to have terrible anxiety, fatigue, insomnia, and crying fits. For the record, that's just not me. I have since seen a nurse 3 days ago, and a doctor yesterday, both of which have told me it can't be the Prednisone because I stopped it days ago, and didn't take very much. So either I have either developed a spontaneous anxiety condition, which just happens to have happened while taking Prednisone, or they don't know what they're talking about. Anyone else out there continue to have these kinds of effects even after stopping a short-term regime of Prednisone? Best wishes to all who are having trouble with this nightmare of a medication!