HSA-NPs were developed by a desolvation technique. HSA-NPs were cationized by covalent coupling of hexamethylenediamine on the particle surface. Either anionic or cationic HSA-NPs were injected to determine the effect of surface charge on intravitreal nanoparticle movement. HSA-NPs were injected intravitreally into both normal and laser photocoagulated eyes to examine the effect of the integrity of retinal tissue on the retinal penetration. The retinal penetration of fluorescence labeled anionic HSA-NPs was investigated by confocal microscopy.
The average gestational birth weight was 950 g, and the average gestational age at birth was weeks. Although 9 eyes had stage 4A, 2 had stage 4B retinal detachments. Six eyes had zone II and five eyes had zone I disease. Bevacizumab was injected at an average postgestational age of 38 weeks. A notable reduction in the vascular activity could be observed 1 week later when vitrectomy was performed. With a mean follow-up of months (range, 2-13 months), a favorable outcome could be observed in all eyes. Only one eye with persistent vitreous hemorrhage required reoperation. No complications attributable to the bevacizumab injections were noted.
The InVitria injection assistant, designed by Arnaldo Goncalves, . of the Netherlands, is a disposable device that simplifies intravitreal injections by making the procedure faster and more predictable. The unique design is equipped with a guide tube which is specially oriented to ensure a fixed injection angle, position, and depth. Use of the InVitria ensures a predictable and fast procedure without the need for instruments like a speculum, calibrator or pressure plate.
After preparing the patient for the procedure, the InVitria is carefully placed on the patient's eye using the positioning line in the center of the device. By gently pushing down and turning the device, the eye becomes fixated and the patient feels an anesthetic effect due to the pressure. With the patient unable to move the eye or see the needle, the physician can safely insert the injection into the eye using the guide tube of the InVitria device, ensuring the proper angle, depth and distance from the limbus. The point of injection is always at from the orientation line. Turning the InVitria after removing the needle gives a stepped injection hole due to the displacement of the conjunctiva.
Because of it's simple use, the Goncalves InVitria injection assistant is very user-friendly, patient-friendly and budget-friendly.