The time of onset of lower urinary tract symptoms varies depending, in part, on the severity and chronicity of ketamine use; however, it is unclear whether the severity and chronicity of ketamine use corresponds linearly to the presentation of these symptoms. All reported cases where the user consumed greater than 5 g/day reported symptoms of the lower urinary tract.  Urinary tract symptoms appear to be most common in daily ketamine users who have used the drug recreationally for an extended period of time.  These symptoms have presented in only one case of medical use of ketamine. However, following dose reduction, the symptoms remitted.