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Binding of an agent to the 3' cap of telomeric DNA can interfere with the telomerase enzyme and give the appearance of a telomerase inhibitor, providing a novel mechanism of action for anti-cancer therapy with interest to life extension. [68] Compounds that tend to associate with this target are large aromatic compounds with a polar charge, [69] [70] and Berberine has been found to bind to this target with a 1:1 stoichiometric ratio with relatively high affinity; [71] which has preceded Berberine derivatives being synthesized for higher affinity. [72] [73] Binding specificities for Berberine can be read here. [74]

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