A common piriformis injection therapy is steroid anti-inflammatories into the piriformis area, either blind or under ultrasound or fluoroscopic guidance. Finally, if none of that works, shockwave therapy may be tried. The idea here is to cause irritation in the muscle to try and kick off a healing response. Botox is another common piriformis injection concept. The idea here is that the Botox will temporarily relax the muscle. Finally, yet another piriformis injection strategy is platelet rich plasma (PRP). The idea here is that the growth factors in the PRP will help heal the damaged muscle and tendon.