Diamond blackfan anemia steroid treatment

Many patients with DBA are treated with blood transfusions , often monthly, to bring their red blood cell count up to an acceptable level. The body normally recycles iron from old red blood cells when producing new ones but this does not happen in DBA patients. Frequent transfusions cause the accumulation of iron in the body. Iron overload can cause damage to the major organs if not properly managed and so patients must take a “chelation” drug to remove excess iron from their bodies. Often this takes the form of a nightly infusion of medication (Desferal) via a subcutaneous needle over a ten hour period. In other cases an oral drug (Exjade) can be taken daily.

Folate and vitamin B 12 deficiencies are the second and third most common causes of nutritional anemia in the world, respectively (iron deficiency is the first) [83, 90] . The major difference in the clinical manifestation between these two deficiencies is that only B 12 deficiency manifests neurologic symptoms. The vitamin B 12 stores in body are so large relative to the daily requirements that it takes years of inadequate supply before clinical symptoms develop. On the contrary, symptoms of megaloblastic anemia due to folate deficiency can occur within a few months after its supply is diminished [83] .

A medical approach that is not currently part of standard practice. Complementary medicine is used along with standard medicine. Alternative medicine is used in place of standard medicine. Example of CAM therapies are acupuncture, chiropractic, homeopathic, and herbal medicines. There is no complementary or alternative therapy that effectively treats bone marrow failure. Some CAM therapies may even hinder the effectiveness of standard medical care. <strong>Patients should talk with their doctor if they are currently using or considering using a complementary or alternative therapy.</strong>

A common complication of DBA is iron overload, which can affect the heart and liver. It results from the transfusions required for treatment. Treatment may include iron chelation drugs that remove iron from the blood to prevent complications. Steroids can have significant side effects, such as osteoporosis, weight gain, high blood pressure, and diabetes mellitus , all of which need to be monitored no matter the age of the patient. Younger patients are at particular risk for growth retardation. They may need a change in their treatment plan to ensure adequate growth in the first year of life.

Diamond blackfan anemia steroid treatment

diamond blackfan anemia steroid treatment

A common complication of DBA is iron overload, which can affect the heart and liver. It results from the transfusions required for treatment. Treatment may include iron chelation drugs that remove iron from the blood to prevent complications. Steroids can have significant side effects, such as osteoporosis, weight gain, high blood pressure, and diabetes mellitus , all of which need to be monitored no matter the age of the patient. Younger patients are at particular risk for growth retardation. They may need a change in their treatment plan to ensure adequate growth in the first year of life.

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